Table 3.
Biological process networks for 250 genes whose expression in peripheral CD4+ cells was positively correlated with serum IL-8 concentration.
| Networks | Total | P value | False discovery rate | In data | Network objects from active data |
|---|---|---|---|---|---|
| Cytoskeleton_Actin filaments | 176 | 2.12E-05 | 2.31E-03 | 10 | Actin muscle, Talin, Tropomyosin, RhoA, Myosin I, CAPZA, MELC, TARA, Actin, CAPZA1 |
|
| |||||
| Cytoskeleton_Regulation of cytoskeleton rearrangement | 183 | 8.79E-04 | 3.67E-02 | 8 | Actin muscle, Talin, RhoA, CAPZA, MELC, TARA, Actin, CAPZA1 |
|
| |||||
| Development_Skeletal muscle development | 144 | 1.01E-03 | 3.67E-02 | 7 | ACTA2, Smooth muscle myosin, Actin muscle, Tropomyosin, RhoA, MELC, Actin |
|
| |||||
| Muscle contraction | 173 | 2.90E-03 | 6.54E-02 | 7 | ACTA2, Syntrophin B, Smooth muscle myosin, Actin muscle, Tropomyosin, MELC, Actin |
|
| |||||
| Immune response_Phagocytosis | 222 | 3.00E-03 | 6.54E-02 | 8 | ILT2, Talin, CD63, RhoA, Myosin I, MSR1, MELC, Actin |
|
| |||||
| Cell adhesion_Integrin priming | 110 | 7.22E-03 | 1.17E-01 | 5 | ACTA2, ITGA2B, Talin, Integrin, Actin |
|
| |||||
| Cell adhesion_Platelet aggregation | 158 | 7.84E-03 | 1.17E-01 | 6 | COX-1 (PTGS1), Talin, RhoA, ENP1, MELC, GP-IB beta |
|
| |||||
| Cell adhesion_Integrin-mediated cell-matrix adhesion | 214 | 9.17E-03 | 1.17E-01 | 7 | ITGA2B, ITGB5, Talin, Integrin, RhoA, MELC, Actin |
|
| |||||
| Inflammation_Amphoterin signaling | 118 | 9.64E-03 | 1.17E-01 | 5 | ITGAM, MyD88, RhoA, MELC, Actin |
|
| |||||
| Proteolysis_Proteolysis in cell cycle and apoptosis | 125 | 1.22E-02 | 1.33E-01 | 5 | Presenilin 2, Cathepsin C, FBX6, Pseudo-ICE, Presenilin |