Table 4.
Biological process networks for 586 genes whose expression in peripheral CD4+ cells was negatively correlated with serum IL-8 concentration.
| Networks | Total | P value | False discovery rate | In data | Network objects from active data |
|---|---|---|---|---|---|
| Muscle contraction | 173 | 2.69E-03 | 1.78E-01 | 7 | K(+) channel, subfamily J, Dystrophin, PKC-alpha, MyHC, PKC, Titin, cPKC (conventional) |
|
| |||||
| Development_Blood vessel morphogenesis | 228 | 3.26E-03 | 1.78E-01 | 8 | PDE3B, PKC-alpha, COL18A1, PDE, PDE9A, TERT, PDE7A, Endomucin |
|
| |||||
| Cardiac development_Wnt_beta-catenin, Notch, VEGF, IP3 and integrin signaling | 150 | 5.75E-03 | 2.09E-01 | 6 | PKC-alpha, Polycystin, CHIBBY, MyHC, Titin, LRP6 |
|
| |||||
| Cardiac development_FGF_ErbB signaling | 124 | 1.12E-02 | 3.05E-01 | 5 | PKC-alpha, Polycystin, MyHC, Titin, gp130 |
|
| |||||
| Development_Skeletal muscle development | 144 | 2.02E-02 | 4.41E-01 | 5 | Dystrophin, HDAC7, Histone deacetylase class II, MyHC, Titin |
|
| |||||
| Proliferation_Positive regulation cell proliferation | 221 | 3.32E-02 | 5.15E-01 | 6 | PUR-alpha, RASGRF1, COL18A1, IGF-1 receptor, IL-11 receptor, gp130 |
|
| |||||
| Development_Cartilage development | 66 | 3.51E-02 | 5.15E-01 | 3 | TR-alpha, Noggin, Aggrecanase-1 |
|
| |||||
| Reproduction_Spermatogenesis, motility and copulation | 228 | 3.78E-02 | 5.15E-01 | 6 | MSK1, MFGE8, Oct-3/4, IGF-1 receptor, PKC, ZFP37 |
|
| |||||
| Reproduction_Male sex differentiation | 243 | 4.90E-02 | 5.41E-01 | 6 | MSK1, Oct-3/4, IGF-1 receptor, PKC, ZFP37, PMEPA1 |
|
| |||||
| Transcription_Chromatin modification | 127 | 4.97E-02 | 5.41E-01 | 4 | SATB1, MSK1, HDAC7, Histone deacetylase class II |