FIG 6 .

Schematic of vesicle trafficking changes associated with LMP1 or LMP2A expression. Proteins significantly different with LMP1 expression are in red text, and proteins affected by LMP2A are in blue text. Only Rab1 and Rab7 were altered by both LMP1 and LMP2A expression. Although there are few proteins altered by both LMP1 and LMP2A, there is important overlap in the stages of vesicle trafficking predicted to be modulated by their individual expression. Both LMP1 and LMP2A affect the expression of different V-ATPase subunits potentially modulating lysosome activity, and both likely affect mTORC1 signaling via alternate intermediaries. In addition, LMP1 appears to affect the recycling endosome through Rab11/Rab11FIP1, while LMP2A affects the exocyst complex. CCV, Clathrin-coated vesicle; MVB, multivesicular body.