TABLE 4 .
Ubiquitination pathway proteins based on manual curation
| Comparison and protein | Entrez gene name | P value | Fold change |
|---|---|---|---|
| LMP1 vs pBabe: no inhibitors | |||
| VBP1 | Von Hippel-Lindau binding protein 1 | 1.50E−02 | −4.055781694 |
| CCDC50 (Ymer) | Coiled-coil domain containing 50 | 4.08E−02 | 2.574692252 |
| BAG2 | BCL2-associated athanogene 2 | 1.56E−02 | −1.975596065 |
| THOC1 (HPR1) | THO complex 1 | 7.01E−03 | −2.12573241 |
| LMP2 versus pBabe: no inhibitors | |||
| RPS25 | Ribosomal protein S25 | 3.99E−02 | 1.423354477 |
| SPG20 (Spartin) | Spastic paraplegia 20 (Troyer syndrome) | 1.20E−03 | 2.185767576 |
| LMP1 versus pBabe: with inhibitors | |||
| DCAF4L2 | DDB1- and CUL4-associated factor 4-like protein 2 | 3.00E−03 | 1.997755058 |
| FBXL18 | Isoform 4 of F-box/LRR-repeat protein 18 | 1.08E−02 | 2.490401919 |
| FBXO7 | F-box only protein 7 | 4.35E−02 | 1.868799777 |
| PSMG1 | Isoform 2 of proteasome assembly chaperone 1 | 2.51E−02 | −1.933470638 |
| SH3RF2 | Putative E3 ubiquitin-protein ligase SH3RF2 | 1.22E−02 | 1.739935853 |
| TRIM27 | Isoform beta of zinc finger protein RFP | 2.37E−02 | 1.677203226 |
| UBAP1 | Isoform 2 of ubiquitin-associated protein 1 | 5.99E−03 | 1.662662369 |
| UBE2K | Ubiquitin-conjugating enzyme E2 K | 1.86E−03 | −1.489748169 |
| UBR7 | Putative E3 ubiquitin-protein ligase UBR7 | 4.61E−02 | 0.364044384 |
| UFL1 | E3 UFM1-protein ligase 1 | 3.58E−02 | −1.27422905 |
| UFM1 | Ubiquitin-fold modifier 1 | 4.72E−02 | 1.622521302 |
| COPS6 | COP9 signalosome complex subunit 6 | 5.68E−03 | −1.935473811 |
| LMP2 vs pBabe: with inhibitors | |||
| ATXN3L | Putative ataxin-3-like protein | 2.32E−02 | 23.37327866 |
| ATXN7L3 | Ataxin-7-like protein 3 | 4.19E−02 | 1.367686338 |
| CBX4 | E3 SUMO-protein ligase CBX4 | 4.31E−02 | 1.424713914 |
| CCM2 | Isoform 2 of malcavernin | 1.69E−02 | −2.262188449 |
| COPS6 | COP9 signalosome complex subunit 6 | 3.01E−05 | −2.303932902 |
| FBXO7 | F-box only protein 7 | 1.37E−02 | 1.404454865 |
| PIAS3 | E3 SUMO-protein ligase PIAS3 | 1.35E−02 | 6.19446027 |
| POMP | Proteasome maturation protein | 4.47E−02 | −2.469462113 |
| PSMG1 | Isoform 2 of proteasome assembly chaperone 1 | 6.54E−03 | −1.961205514 |
| RNF114 | RING finger protein 114 | 4.65E−02 | −1.466037981 |
| RNF138 | E3 ubiquitin-protein ligase RNF138 | 2.37E−03 | 1.371846044 |
| SDCBP (MDA-9) | Isoform 3 of syntenin-1 | 2.26E−03 | −1.419647959 |
| UFL1 | E3 UFM1-protein ligase 1 | 2.88E−02 | −1.316652316 |