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. 2018 Jun 19;13:3507–3527. doi: 10.2147/IJN.S166445

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© 2018 Chen et al. This work is published and licensed by Dove Medical Press Limited

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The morphology of nanoparticles: (A) a, water; b, PPP-NPs; c, PPP_Cy5-NPs; d, PPP_Cy5-RH-NPs; e, PPP-RH-NPs. TEM photograph, magnification ×100,000 (B, C) and size distribution (D, E) of PPP-RH-NPs without, or with, high-pressure homogenization treatment. Scale bar is 200 nm. PPP-NPs, PEG-PCL-PEI nanoparticles without loading RH; PPP-RH-NPs, RH-loaded PEG-PCL-PEI nanoparticles.

Abbreviations: Cy5, cyanine 5; PEG-PCL-PEI, polyethyleneglycol-co-polycaprolactone-co-polyethylenimine; RH, rhein; TEM, transmission electron microscopy.