Figure 1.

Gabapentinoids exert no cytotoxic effects on PC12 cells.

Notes: Results of MTT assays with PC12 cells to determine the influence of gabapentinoids on mildly–moderately injured cells in an incubation period of 24 hours. (A) Cells were incubated with gabapentinoids alone (10 and 100 µM); (B) increasing concentrations of hydrogen peroxide; (C) coincubation with H₂O₂ and 100 µM gabapentin (Gbp); (D) coincubation with H₂O₂ and 100 µM pregabalin (Pgb); and (E) coincubation with 100 nM vincristine and 100 µM Gbp or 100 µM Pgb. Cell viability depicted as percentage of control. ^*P<0.05; ^***P<0.001.