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. Author manuscript; available in PMC: 2019 Jun 19.
Published in final edited form as: Biochemistry. 2018 Apr 30;57(24):3326–3337. doi: 10.1021/acs.biochem.8b00315

Figure 6.

Figure 6

Quiescent Affinity Label As a Covalent Inhibitor. The reaction of 2-methyl-4-chloropyridine with the active-site Cys thiolate of dimethylarginine dimethylaminohydrolase (DDAH) is catalyzed by a neighboring Asp residue.