. Author manuscript; available in PMC: 2019 Apr 1.

Published in final edited form as: Ecol Appl. 2018 Apr;28(3):605–611. doi: 10.1002/eap.1698

Table 1.

Phylogenetic signal in fish LC₅₀ values by chemical class

Chemical	Class	Mode of Action^*	N	Temp t-Value	Temp p-Value	λ Value
Azinphos-methyl	Organophosphate	AChE	18	0.79	0.44	0.995^a
Chlorpyrifos	Organophosphate	AChE	15	0.67	0.51	0.584^b
Coumaphos	Organophosphate	AChE	10	0.11	0.91	0.0^b
Diazinon	Organophosphate	AChE	13	0.43	0.67	1.0^a
Dichlorvos	Organophosphate	AChE	10	0.12	0.91	1.0^a
EPN	Organophosphate	AChE	12	−2.3	0.043	0.981
Fenitrothion	Organophosphate	AChE	14	1.4	0.18	0.223^b
Malathion	Organophosphate	AChE	25	1.7	0.095	0.979^a
Methylparathion	Organophosphate	AChE	14	1.7	0.12	0.723^a
Parathion	Organophosphate	AChE	11	−2.6	0.027	1.0^a
Phorate	Organophosphate	AChE	10	−1.1	0.30	0.845
Trichlorfon	Organophosphate	AChE	15	0.37	0.72	0.891^a^,^b
Aminocarb	Carbamate	AChE	11	−2.4	0.039	0.97
Carbaryl	Carbamate	AChE	33	2.6	0.013	0.0^b
Carbofuran	Carbamate	AChE	10	0.51	0.62	1.0
Methomyl	Carbamate	AChE	11	−2.0	0.075	0.0^b
Mexacarbate	Carbamate	AChE	17	0.76	0.46	0.0^b
Chlordane	Organochlorine	Neurotoxicity	14	7.7	<0.001	0.0
DDT	Organochlorine	Neurotoxicity	25	0.97	0.34	0.246^b
Endosulfan	Organochlorine	Neurotoxicity	14	−0.33	0.74	0.0
Endrin	Organochlorine	Neurotoxicity	20	1.7	0.11	0.0^b
Heptochlor	Organochlorine	Neurotoxicity	10	0.16	0.88	1.0
Lindane	Organochlorine	Neurotoxicity	15	1.6	0.16	0.574^a
Methoxychlor	Organochlorine	Neurotoxicity	18	3.3	0.004	0.0^b
Pentochlorophenol	Organochlorine	Neurotoxicity	20	−0.82	0.42	0.833^b
Toxaphene	Organochlorine	Neurotoxicity	15	1.9	0.08	0.0^b
Cadmium	Metal	MIOI	13	2.9	0.014	0.0^b
Chromium (VI)	Metal	MIOI	15	1.1	0.28	0.0^b
Copper	Metal	MIOI	46	2.6	0.012	0.601^b
Zinc	Metal	MIOI	28	2.9	0.001	0.0^b
Bioethanomethrin	Pyrethroid	Neurotoxicity	11	−1.2	0.27	0.942^a
Permethrin	Pyrethroid	Neurotoxicity	16	1.4	0.18	0.0^b
S-Bioallethrin	Pyrethroid	Neurotoxicity	10	3.0	0.017	0.817
3-Chloro-3-nitrosalicylanilide	Nitroaromatic	Non-polar Narcosis	10	0.86	0.41	0.0^b
Clonitralid	Nitroaromatic	ETI	10	−0.30	0.77	0.0
Dinitramine	Nitroaromatic	ETI	10	–^c	–^c	0.322^b
Ammonia	Inorganic	ETI	26	1.1	0.28	0.0
Potassium Permanganate	Inorganic	Reactivity	11	0.20	0.85	0.0
4-Nonylphenol	Phenol	Polar Narcosis	10	1.1	0.31	0.0^b
Phenol	Phenol	Polar Narcosis	10	2.8	0.022	0.69
Antimycin A	Antibiotic	ETI	14	2.9	0.013	0.514^b
Captan	Phthalamide	Non-polar Narcosis	10	−0.16	0.87	0.912^a

Mode of action classified according to Barron et al. (2015). AChE: acetylcholinesterase inhibition; Neurotoxicity: MIOI: Metallic iono/osmoregulatory impairment; ETI: electron transport inhibition.

λ significantly different from 0

λ significantly different from 1

All species tested at 12°C