Fig. 6. In vivo TPM images of the frontal cortex of transgenic 5XFAD mice at (a) 0, (b) 30, (c) 60 and (d) 150 min after i.v. injection of QAD1 (10 mg kg^–1). (e) 230 sections of TPM images along the z-direction at the depth of ∼300 μm from the surface of the cortex were accumulated to visualize Aβ plaques distribution. (f and g) 3D reconstructed TP image of the frontal cortex of transgenic 5XFAD mice after i.v. injection of QAD1 (10 mg kg^–1) and dextran 40 kDa-Texas red. Approximately 270 sections of TPM images were acquired along the z-direction at a depth of ∼300 μm from the surface of the cortex. Scale bars: (a) 50 and (e) 30 μm.