Scheme 1. Chemical structures of 1–3 and their synthetic route: Reagents and conditions: (a) KOtBu, THF, 0–20 °C; (b) P(OEt)3, 125 °C; (c) i: compound 1, 2-bromoethylacetate, NaH, 18-Crown-6, THF, 80 °C; ii: NaOMe, CH3OH, 0–20 °C.
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