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. 2018 May 9;293(25):9854–9868. doi: 10.1074/jbc.RA118.002540

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© 2018 Kasetti et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 8. — Inhibition of TGFβ signaling via treatment with LY364947 reduces Dex-induced ocular hypertension in mice. BL6 mice were treated with weekly periocular injections of Veh or Dex acetate suspension; topical ocular LY364947 (LY) eye drops were given to the right eyes, and the contralateral left eyes were given vehicle control eye drops twice daily after 1 week of periocular injections. The left eyes, treated with periocular Dex and vehicle eye drops, developed significantly elevated IOP after 2 and 3 weeks of treatment compared with periocular Veh-injected mice. The right eyes, treated with periocular Dex acetate suspension and LY364947 eye drops, demonstrated significant reduction in IOP compared with the contralateral left eyes treated with periocular Dex acetate suspension and vehicle eyes drops (n = 4 in periocular Veh-treated group and n = 8 in periocular Dex-treated group; two-way ANOVA). ###, p < 0.001 versus periocular Veh + vehicle control eye drops; ***, p < 0.001versus periocular Dex + vehicle eye drops.