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Hyperpolarized [1-13C]pyruvate 13C magnetic resonance spectra from mouse hearts treated with PDK inhibitors. A, lean mouse. B, DIO mouse with DMSO control. C, DIO mouse with PS-10. D, DIO mouse with DCA. The numbers denote metabolite signals as follows: 1, [1-13C]aspartate; 2, [4-13C]aspartate; 3, [4-13C]malate; and 4, [1-13C]malate.
