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A working model of PS10 activating pyruvate dehydrogenase complex in obese mouse hearts. A, in obese/type 2 diabetes stage, PDKs are elevated to inhibit PDC activity, followed by reducing energy production from glucose, accumulation of lactate and increase of anaplerosis. B, with the treatment of PDK inhibitors, like PS10, PDC is active to utilize more glucose as fuel to increase energy production, and reduces both lactate accumulation and anaplerosis.
