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LGR4 binding–defective R2Fu mutant potentiated Wnt/β-catenin signaling. A and B, saturation binding of R2Fu-WT, -F109A, and -RQ to HEK293T cells stably expressing LGR4 (A) or transiently expressing ZNRF3-ECDTM (B). C and D, TOPFlash results of R2Fu-WT and the two mutants in parental STF cells (C) or STF-LGR4KO cells (D). All error bars represent S.E. Max., maximum; Act., activity.
