Figure 6.

Hepatic LRP1 deficiency promotes monocyte-macrophage infiltration into the liver. The hLrp1^+/+ and hLrp1^−/− mice were fed the HFHC diet for 16 weeks. Liver sections were prepared from these animals for immunofluorescence detection of F4/80 (top panels) and CD68⁺ cells (middle panels). The number of F4/80⁺ and CD68⁺ cells in the livers of hLrp1^+/+ (filled bars) and hLrp1^−/− (open bars) mice were also quantified by flow cytometry. The data represent mean ± S.E. *, significant difference from hLrp1^+/+ mice at p < 0.01.