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. 2018 May 11;293(25):9685–9695. doi: 10.1074/jbc.RA118.002492

Figure 1.

Figure 1.

Deletion of the EP3 receptor reduces mechanical allodynia in the SNI model for neuropathic pain. A, LC–MS/MS analysis of PGE2 levels in the sciatic nerve, DRGs (L3–L5) and spinal cord (L3–L5) in naïve mice and 14 days after SNI. The data are shown as means ± S.E. (n = 5). **, p ≤ 0.01; two-tailed t test. B–E, C57BL/6N mice and EP receptor knockout mice underwent SNI surgery. Mechanical thresholds were measured before and at the indicated times after SNI. The data are shown as means ± S.E. B–D, WT, n = 15. B, EP1−/−, n = 7. C, EP2−/−, n = 8. D, EP3−/−, n = 13. E, EP4−/−, n = 6. *, p < 0.05; **, p ≤ 0.01; ***, p ≤ 0.001; two-way ANOVA with Bonferroni post hoc test. BL, baseline; d, days; PW, paw withdrawal.