Figure 2.

S0859 did not affect SLO1 and SLO3 channels. A, SLO3 recordings. The currents were evoked by voltage pulses from −100 to +80 mV in 10-mV steps at a holding potential of −70 mV. Traces represent currents of the same oocyte subsequently recorded in: control conditions (ND96 solution in the bath); after the application of 5 μm S0859, after the wash with ND96 and treated with 1 mm Ba²⁺. B, mean current-voltage relationships ± S.E. in control conditions and in the presence of S0859 and Ba²⁺ with respect to the control condition at −80 mV (n = 4 oocytes). C, summarizes the current measurements at 60 mV normalized to control condition (I₀). D, SLO1 recordings. The currents were evoked by voltage pulses from −100 to +80 mV in 10-mV steps at a holding potential of −70 mV in control conditions (ND96 solution in the bath), after the application of 5 μm S0859, after the wash with ND96 and treated with 5 mm TEA. E, mean current-voltage relationships ± S.E. in control conditions and during the application of S0859 and TEA with respect to control condition at −80 mV (n = 4 oocytes). F, summarizes the current measurements at 60 mV normalized by control condition (I₀).