Table S1.
Descriptive characteristics of study participants born since 1987
| Characteristics | NF | Nonfamilial NF | Familial NF | NF-matched controls | Other phacomatoses combined | Nonfamilial phacomatoses | Familial phacomatoses | Other phacomatoses-matched controls |
|---|---|---|---|---|---|---|---|---|
| Number of participants (%) | 1074 | 644 (60) | 430 (40) | 10740 | 1169 | 1010 (86) | 159 (14) | 11690 |
| Paternal age in years, mean, SD | 33.14, 0.19 | 33.84, 0.27 | 32.09, 0.28 | 32.42, 0.06 | 32.48, 0.18 | 32.45, 0.19 | 32.67, 0.49 | 32.00, 0.06 |
| Maternal age in years, mean, SD | 29.69, 0.16 | 30.16, 0.21 | 28.97, 0.24 | 29.65, 0.05 | 29.31, 0.15 | 29.26, 0.16 | 29.59, 0.39 | 29.09, 0.05 |
| Sex, n (%) | ||||||||
| Male | 578 (54) | 365 (57) | 213 (50) | 5780 (54) | 643 (55) | 559 (55) | 84 (53) | 6430 (55) |
| Female | 496 (46) | 279 (43) | 217 (50) | 4960 (46) | 526 (45) | 451 (45) | 75 (47) | 5260 (45) |
| Parental education level, n (%) | ||||||||
| Lowa | 69 (6) | 38 (6) | 31 (7) | 402 (4) | 54 (5) | 48 (5) | 6 (4) | 471 (4) |
| Intermediateb | 547 (51) | 278 (43) | 269 (63) | 4757 (44) | 522 (45) | 447 (44) | 75 (47) | 5399 (46) |
| Highc | 456 (43) | 326 (51) | 130 (30) | 5570 (52) | 592 (51) | 514 (51) | 78 (49) | 5801 (50) |
| Missing | 2 (0) | 2 (0) | – | 11 (0) | 1 (0) | 1 (0) | – | 19 (0) |
| Parental country of birth,d n (%) | ||||||||
| Nordic countries | 878 (82) | 515 (80) | 363 (84) | 8855 (82) | 990 (85) | 863 (85) | 127 (80) | 9879 (85) |
| Non-Nordic countries | 196 (18) | 129 (20) | 67 (16) | 1885 (18) | 179 (15) | 147 (15) | 32(20) | 1811 (15) |
| Birth year, n (%) | ||||||||
| 1987–1989 | 168 (16) | 105 (16) | 63 (15) | 1680 (16) | 360 (31) | 327 (32) | 33 (21) | 3600 (31) |
| 1990–1999 | 497 (46) | 304 (47) | 193 (45) | 4970 (46) | 635 (54) | 543 (54) | 92 (58) | 6350 (54) |
| 2000–2010 | 409 (38) | 235 (37) | 174 (40) | 4090 (38) | 174 (15) | 140 (14) | 34 (21) | 1740 (15) |
| Type of phacomatoses, n (%) | ||||||||
| Tuberous sclerosis complex | – | – | – | – | 220 | 164 (75) | 56 (25) | – |
| von Hippel–Lindau disease | – | – | – | – | 29 | 6 (21) | 23 (79) | – |
| Ataxia telangiectasia | – | – | – | – | 12 | 7 (58) | 5 (42) | – |
| Others | – | – | – | – | 908 | 833 (92) | 75 (8) | – |
Notes:
a
Low, elementary school;
b
Intermediate, high school or apprenticeship;
c
High, university or postgraduate university (parental education was defined by the highest household education level);
d
Parental country of birth was considered as Nordic countries if the country of birth of either of the parents was defined as Nordic.
Abbreviation: NF, neurofibromatosis.