Table S2.

Odds ratios of familial and nonfamilial neurofibromatosis in offspring born since 1987 according to parental age at birth

Parental age (years)	Nonfamilial neurofibromatosis						Familial neurofibromatosis
	Number of cases	Number of controls	Crude OR	95% CI	Adjusted ORa	95% CIa	Number of cases	Number of controls	Crude OR	95% CI	Adjusted ORa	95% CIa
Paternal age
<25	39	500	0.96	0.66–1.39	0.99	0.67–1.47	32	318	0.94	0.63–1.42	0.76	0.49–1.19
25–29	138	1701		(Reference)		(Reference)	118	1109		(Reference)		(Reference)
30–34	198	2174	1.13	0.90–1.42	1.09	0.86–1.40	149	1419	0.99	0.76–1.27	1.18	0.89–1.56
35–39	148	1312	1.39	1.09–1.78	1.37	1.04–1.81	81	891	0.85	0.63–1.15	1.13	0.80–1.59
≥40	121	753	1.98	1.53–2.57	1.94	1.42–2.65	50	563	0.83	0.59–1.18	1.21	0.80–1.83
Continuous	644	6440	1.04	1.03–1.05	1.04	1.03–1.06	430	4300	0.99	0.97–1.00	1.01	0.99–1.04
Maternal age
<25	87	1092	0.84	0.65–1.09	0.87	0.65–1.17	83	692	1.09	0.83–1.46	1.05	0.76–1.44
25–29	202	2163		(Reference)		(Reference)	158	1446		(Reference)		(Reference)
30–34	224	2055	1.17	0.96–1.43	1.04	0.84–1.29	124	1354	0.83	0.65–1.07	0.86	0.66–1.12
35–39	103	940	1.19	0.92–1.53	0.89	0.67–1.19	57	644	0.80	0.58–1.11	0.84	0.58–1.22
≥40	28	190	1.61	1.05–2.47	1.04	0.65–1.66	8	164	0.44	0.21–0.91	0.46	0.21–1.00
Continuous	644	6440	1.02	1.01–1.04	0.99	0.97–1.01	430	4300	0.97	0.95–0.99	0.98	0.95–1.01

Note:

^aAdjusted for maternal and paternal education, parental country of birth, and mutually adjusted for paternal and maternal ages.