Table S3.

Odds ratios of familial and nonfamilial other phacomatoses combined in offspring born since 1987 according to parental age at birth

Parental age (years)	Nonfamilial phacomatoses						Familial phacomatoses
	Number of cases	Number of controls	Crude OR	95% CI	Adjusted ORa	95% CI	Number of cases	Number of controls	Crude OR	95% CI	Adjusted ORa	95% CI
Paternal age
<25	75	925	0.86	0.66–1.13	0.80	0.60–1.06	6	133	0.39	0.17–0.94	0.37	0.15–0.91
25–29	267	2845		(Reference)		(Reference)	51	443		(Reference)		(Reference)
30–34	322	3246	1.05	0.89–1.25	1.11	0.92–1.33	50	514	0.85	0.56–1.28	0.87	0.56–1.35
35–39	216	1964	1.18	0.97–1.42	1.25	0.99–1.55	31	318	0.85	0.53–1.37	0.86	0.50–1.49
≥40	130	1120	1.24	0.99–1.54	1.32	1.01–1.72	21	182	1.00	0.58–1.72	0.95	0.49–1.85
Continuous	1010	10100	1.01	1.00–1.02	1.02	1.00–1.03	159	1590	1.01	0.99–1.04	1.01	0.97–1.04
Maternal age
<25	203	2026	1.06	0.89–1.27	1.19	0.98–1.46	26	276	0.91	0.56–1.47	1.04	0.62–1.74
25–29	339	3584		(Reference)		(Reference)	58	558		(Reference)		(Reference)
30–34	297	2937	1.07	0.91–1.26	0.98	0.82–1.17	47	507	0.89	0.59–1.34	0.93	0.59–1.43
35–39	138	1261	1.16	0.94–1.44	0.99	0.78–1.27	23	196	1.12	0.67–1.87	1.18	0.65–2.17
≥40	33	292	1.19	0.82–1.74	0.99	0.66–1.49	5	53	0.91	0.35–2.38	0.87	0.29–2.52
Continuous	1010	10100	1.01	0.99–1.02	0.99	0.98–1.01	159	1590	1.01	0.98–1.04	1.01	0.96–1.05

Note:

^aAdjusted for maternal and paternal education, parental country of birth, and mutually adjusted for paternal and maternal ages.