Table 1.
Bodyweight (BW) at study start and euthanasia, rectus femoris muscle mass, and length of the femur.
| BW at study start (g) | BW at euthanasia (g) | Change in BW from study start to euthanasia (%) | Rectus femoris muscle mass (mg) | Femur length (mm) | |
|---|---|---|---|---|---|
| Base | − | 22.7 ± 1.2 | − | 65.5 ± 8.6 | 15.41 ± 0.25 |
| Ctrl | 22.2 ± 1.0 | 22.2 ± 1.4 | 0.1 ± 3.4 | 66.5 ± 8.3 | 15.56 ± 0.24 |
| BTX | 22.2 ± 0.9 | 20.5 ± 0.7 a,b | -7.5 ± 2.6 b | 34.8 ± 3.8 a,b | 15.44 ± 0.26 |
| BTX+Zol | 22.9 ± 1.4 | 21.2 ± 1.2 a,b,c | -7.1 ± 4.4 b | 33.8 ± 4.1 a,b | 15.51 ± 0.32 |
16-week-old C57BL/6J female mice immobilized with botulinum toxin (BTX) and treated with zoledronic acid (Zol) compared with baseline (Base) and control (Ctrl) mice.
a
denotes a significant difference (p<0.05) from Base,
b
denotes a significant difference (p<0.05) from Ctrl, and
c
denotes a significant difference (p<0.05) from BTX. Mean ± SD.