Table 4.
Micro Computed tomography (µCT) of the distal femoral metaphysis and epiphysis.
| Tb.N (1/mm) | Tb.Sp (µm) | Conn.D (1/mm3) | SMI (-) | TMD (mg/cm3 of HA) | |
|---|---|---|---|---|---|
| Distal femoral metaphysis | |||||
| Base | 3.56 ± 0.19 | 281 ± 15 | 187 ± 39 | 2.12 ± 0.18 | 874 ± 13 |
| Ctrl | 3.30 ± 0.25 a | 304 ± 23 a | 135 ± 30 a | 2.26 ± 0.24 | 891 ± 10 a |
| BTX | 3.00 ± 0.25 a,b | 331 ± 27 a,b | 112 ± 35 a | 2.34 ± 0.16 a | 844 ± 10 a,b |
| BTX+Zol | 3.49 ± 0.26 c | 287 ± 20 c | 153 ± 46 | 1.70 ± 0.19 a,b,c | 908 ± 7 a,b,c |
| Distal femoral epiphysis | |||||
| Base | 5.75 ± 0.85 | 195 ± 23 | 291 ± 36 | 0.32 ± 0.10 | 971 ± 8 |
| Ctrl | 5.32 ± 0.41 | 212 ± 16 | 206 ± 35 a | 0.22 ± 0.24 | 987 ± 10 a |
| BTX | 4.62 ± 0.53 a,b | 228 ± 21 a,b | 305 ± 51 b | 1.16 ± 0.14 a,b | 925 ± 13 a,b |
| BTX+Zol | 5.65 ± 0.48 c | 199 ± 16 c | 218 ± 22 a,c | 0.20 ± 0.12 c | 989 ± 10 a,c |
16-week-old C57BL/6J female mice immobilized with botulinum toxin (BTX) and treated with zoledronic acid (Zol) compared with baseline (Base) and control (Ctrl) mice. Trabecular number (Tb.N), trabecular spacing (Tb.Sp), connectivity density (Conn.D), structure model index (SMI), tissue mineral density (TMD), and hydroxyapatite (HA).
a
denotes a significant difference (p<0.05) from Base,
b
denotes a significant difference (p<0.05) from Ctrl, and
c
denotes a significant difference (p<0.05) from BTX. Mean ± SD.