Table 5.
Dynamic bone histomorphometry of the distal femoral metaphysis and epiphysis.
| Day 9-13 | Day 13-17 | |||||
|---|---|---|---|---|---|---|
| MS/BS (%) | MAR (µm/d) | BFR/BS (µm3/µm2/d) | MS/BS (%) | MAR (µm/d) | BFR/BS (µm3/µm2/d) | |
| Distal femoral metaphysis | ||||||
| Base | - | - | - | - | - | - |
| Ctrl | 48.7 ± 9.3 | 1.91 ± 0.35 | 0.92 ± 0.17 | 54.9 ± 8.1 | 2.07 ± 0.29 | 1.13 ± 0.20 |
| BTX | 33.3 ± 4.8 b | 2.17 ± 0.26 | 0.72 ± 0.15 b | 47.3 ± 3.6 b | 2.33 ± 0.27 b | 1.10 ± 0.14 |
| BTX+Zol | 32.3 ± 6.6 b | 1.09 ± 0.19 b,c | 0.35 ± 0.10 b,c | 29.7 ± 8.0 b,c | 1.40 ± 0.18 b,c | 0.42 ± 0.13 b,c |
| Distal femoral epiphysis | ||||||
| Base | - | - | - | - | - | - |
| Ctrl | 63.3 ± 11.6 | 1.17 ± 0.15 | 0.74 ± 0.15 | 57.6 ± 11.9 | 1.18 ± 0.17 | 0.67 ± 0.13 |
| BTX | 49.1 ± 7.5 b | 1.49 ± 0.16 b | 0.73 ± 0.13 | 62.0 ± 6.4 | 1.69 ± 0.18 b | 1.04 ± 0.14 b |
| BTX+Zol | 20.1 ± 7.1 b,c | 0.75 ± 0.23 b,c | 0.15 ± 0.07 b,c | 17.6 ± 3.9 b,c | 1.20 ± 0.32 c | 0.21 ± 0.06 b,c |
16-week-old C57BL/6J female mice immobilized with botulinum toxin (BTX) and treated with zoledronic acid (Zol) compared with baseline (Base) and control (Ctrl) mice. Mineralizing surfaces (MS/BS), mineral apposition rate (MAR), and bone formation rate (BFR/BS).
b
denotes a significant difference (p<0.05) from Ctrl and
c
denotes a significant (p<0.05) difference from BTX. Mean ± SD.