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Toxicities defined as “Unacceptable” according to COG protocol ANBL0931 (n = 105 patients enrolled).
| Course | Number of patients with unacceptable toxicities | Description of the unacceptable toxicity |
|---|---|---|
| Course 1 (n = 104) | 2 | Grade 4 allergic reaction (AR)/anaphylaxis (n = 1); grade 5 cardiac arrest (n = 1) |
| Course 2 (n = 100) | 1 | Grade 4 AR |
| Course 3 (n = 98) | 1 | Grade 4 AR |
| Course 4 (n = 90) | 1 | Grade 4 anaphylaxis |
| Course 5 (n = 88) | 0 | None |
| Course 6 (n = 81) | 0 | None |
