Table 4.

Proportion of patients (95% confidence interval) with clinically significant Grade 3 and 4 toxicities attributed to ch14.18 on COG study ANBL0931 (courses 1, 3, and 5 contained GM-CSF and Courses 2 and 4 contained IL-2).

	Pain	Allergic reactions	Capillary leak syndrome	Hypotension	Fever
Course 1 (n = 104)	41% (32.4, 51.0%)	3% (0.9, 8.1%)	1% (0.2, 5.2%)	10% (5.3, 16.8%)	21% (14.4, 30.0%)
Course 2 (n = 100)	28% (20.1, 37.5%)	10% (5.5, 17.4%)	4% (1.6, 9.8%)	17% (10.9, 25.6%)	59% (49.2, 68.1%)
Course 3 (n = 98)	22% (15.3, 31.7%)	5% (2.2, 11.4%)	0% (0.0, 3.8%)	4% (1.6, 10.0%)	6% (2.8, 12.7%)
Course 4 (n = 90)	31% (22.5, 41.3%)	7% (3.1, 13.8%)	2% (0.6, 7.7%)	14% (8.6, 23.2%)	32% (23.5, 42.4%)
Course 5 (n = 88)	24% (16.2, 33.7%)	2% (0.6, 7.9%)	0% (0.0, 4.2%)	8% (3.9, 15.5%)	5% (1.8, 11.1%)