Table 7.
Relationship of cytokine and nitrate levels with severe hypotension in ANBL0931 patients.
| Course 1, day 6 |
Course 4, day 90 |
|||||
|---|---|---|---|---|---|---|
| Cytokine or nitrate | None or ≤ gr2 hypotension | hypotension ≥ gr3 | p-Value | None or ≤ gr2 hypotension | hypotension ≥ gr3 | p-Value |
| IL-5 (pg/ml) | N = 42 | N = 4 | p = 0.018 | N = 39 | N = 7 | p > 0.05 |
| Mean ± SE (range) | 1,043.1 ± 162.7 (27.5–5,114.5) | 148.0 ± 51.9 (12.3–264.9) | 1,224.7 ± 211.1 (28.5–5,238.4) | 1,752.0 ± 982.2 (3.6–7,500.9) | ||
| Tumor necrosis factor alpha (pg/ml) | N = 61 | N = 7 | p > 0.05 | N = 54 | N = 8 | p > 0.05 |
| Mean ± SE (range) | 11.8 ± 1.5 (2.5–70.6) | 8.6 ± 1.4 (4.7–13.6) | 19.4 ± 1.3 (5.7–54.4) | 15.3 ± 2.1 (7.0–26.0) | ||
| IFNγ (pg/ml) | N = 61 | N = 7 | p > 0.05 | N = 54 | N = 8 | p > 0.05 |
| Mean ± SE (range) | 48.2 ± 8.2 (1.2–317.2) | 26.2 ± 9.9 (2.2–61.0) | 354.4 ± 89.7 (0.6–2,511.0) | 1,286.5 ± 1,187.9 (3.1–9,591.9) | ||
| IL-6 (pg/ml) | N = 63 | N = 7 | p > 0.05 | N = 55 | N = 8 | p > 0.05 |
| Mean ± SE (range) | 31.8 ± 9.8 (1.7–618. 6) | 19.1 ± 4.7 (2.5–35.5) | 38.3 ± 5.1 (0.9–187.1) | 26.2 ± 5.3 (1.0–54.7) | ||
| Nitrate (μM) | N = 81 | N = 8 | p = 0.04 | N = 67 | N = 10 | p > 0.05 |
| Mean ± SE (range) | 24.2 ± 1.9 (3.5–27.8) | 13.9 ± 3.0 (2.8–27.8) | 28.3 ± 2.4 (5.9–102.0) | 21.0 ± 2.7 (7.6–34.3) | ||
Cytokines or nitrate during course 1 and course 4 of immunotherapy for association with clinically significant (≥grade 3) hypotension. Mann–Whitney U-test comparisons of cytokines were considered significant at a p-value of <0.0125 after Bonferroni correction for the four cytokines measured at each course. Nitrate levels were considered significant at p = 0.05.