Table 8.

Relationship of cytokine and nitrate levels with capillary leak in ANBL0931 patients.

	Course 1, day 6			Course 4, day 90
Cytokine or nitrate	No capillary leaka	Capillary leak ≥ gr2b	p-valuec	No capillary leaka	Capillary leak ≥ gr2d	p-valuec
IL-5 (pg/ml)	N = 30	N = 16	p > 0.05	N = 25	N = 21	p > 0.05
Mean ± SE (range)	903.3 ± 133.4 (27.5–2,787.7)	1,081.4 ± 369.4 (12.3–5,114.5)		757.9 ± 105.8 (3.6–2,175.8)	1,956.1 ± 450.2 (28.5–7,500.9)
IL-6 (pg/ml)	N = 48	N = 22	p > 0.05	N = 39	N = 24	p > 0.05
Mean ± SE (range)	21.0 ± 2.0 (1.7–72.6)	51.4 ± 27.6 (2.5–618.6)		34.8 ± 5.0 (1.0–124.2)	40.0 ± 8.7 (0.9–187.1)
Tumor necrosis factor alpha (TNFα) (pg/ml)	N = 46	N = 22	p > 0.05	N = 38	N = 24	p > 0.05
Mean ± SE (range)	9.6 ± 0.7 (2.5–23.7)	15.4 ± 0.3 (3.0–70.6)		17.6 ± 1.0 (6.0–35.7)	20.8 ± 2.6 (5.7–54.4)
IFNγ (pg/ml)	N = 46	N = 22	p > 0.05	N = 60	N = 24	p > 0.05
Mean ± SE (range)	47.7 ± 10.0 (1.2–317.2)	42.2 ± 10.2 (1.4–194.8)		628.6 ± 266.5 (3.1–9,591.9)	231.0 ± 103.8 (0.6–2,459.6)
Nitrate $\left({\text{NO}}_3^{-}\right)$ (μM)	N = 65	N = 24	p > 0.05	N = 48	N = 29	p > 0.05
Mean ± SE (range)	23.2 ± 2 (2.8–106.41)	23.6 ± 3.3 (3.8–79.9)		25.8 ± 2.5 (5.9–102.0)	29.8 ± 3.8 (7.2–98.7)

^aThere were no grade 1 capillary leak diagnoses.

^bOne patient was diagnosed with grade 3 while the rest were grade 2. Compared to the group as a whole (see Table S2 in Supplementary Material), this patients levels of IL-5 were the lowest, IL-6 the second lowest and TNFα ninth lowest. IFNγ and nitrate appeared similar to the group as a whole (#26 for IFNγ and #69 for nitrate).

^cTest of association of cytokine or nitrate levels with capillary leak (none versus grade ≥ 2) using a two-sided Mann–Whitney U-test at a p-value of < 0.05 without correction for multiple comparisons.

^dTwo patients were diagnosed with grade 3 capillary leak at this time point while the rest were grade 2.