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. 2018 Jun 25;6(12):e13743. doi: 10.14814/phy2.13743

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A): Overview of the increasing doses and numbers of the antihypertensive and diuretic drugs in a timeline. (B) Blood pressure decreased slowly and insufficiently despite several antihypertensive drugs, but at administration of amiloride (week 15), blood pressure, and weight declined promptly and effectively. (C) Combined treatment directed at aldosterone/ENaC resulted in severe hyperkalemia and a decline in kidney function. (D) Addition of amiloride increased urinary sodium excretion. Furthermore, proteinuria decreased.