Figure 1.

Decision support solutions in U-PGx. The U-PGx CDS strategy combines several complementary modes of delivering patient-specific PGx therapeutic recommendations to healthcare providers at the point of care, with or without integration into local EHRs. Active, interruptive CDS alerts clinicians of relevant gene-drug interactions via a pop-up message in the EHR or e-prescription system at the time of prescribing. Passive CDS is delivered either inside the EHR system as a digital report, or outside the EHR system via mobile- and paper-based solutions. The different decision support solutions deployed in the U-PGx project including the underlying knowledgebase are described in detail below.