Figure 5.
Effects of BU10119 (1 mg·kg−1) in adult male CD1 mice in the forced swim test (A) and in the novelty‐induced hypophagia task (B). The SSRI fluoxetine (20 mg·kg−1) was administered as a positive control. The effects of combination of buprenorphine with naltrexone (both at 1 mg·kg−1, BUP/NTX) and the κ antagonist norBNI are also shown. (A) The total time spent swimming, climbing or immobile during the last 4 min of the forced swim session are shown. (B) The latency to drink milk in both the home and novel cage environments is shown. All values are the mean ± SEM (n = 10 per group, separate experimental groups in each figure). *P < 0.05 as compared to saline; #P < 0.05 for comparison between groups.