Table 1.

Pharmacokinetic and pharmacodynamic properties of direct oral anticoagulants^18,19

	Betrixaban	Apixaban	Edoxaban	Rivaroxaban	Dabigatran
Target	Factor Xa	Factor Xa	Factor Xa	Factor Xa	Thrombin
Half-life (h)	19–27	12	10–14	5–9	12–17
Dosing	o.d.	b.i.d.	o.d.	o.d. (b.i.d.)	b.i.d.
Tmax (h)	3–4	1–3	1–2	2–4	2
Bioavailability (%)	34	50	62	66	7
Renal excretion (%)	17.8a	25	35	66	>80
Faecal excretion (%)	85b	46.7–56	62.2	26.4	82–88
CYP450 metabolism	No	Yes	No	Yes	No

b.i.d., twice daily; o.d., once daily; T_max: time to reach peak concentration in plasma after oral dose.

^aUnchanged betrixaban in urine following an intravenous betrixaban dose.

^bFollowing oral administration of radio-labelled betrixaban.