Figure 7.
ChIP analysis of hydroxyflavonoid-induced AhR recruitment to CYP1A1/UGT1A1 gene promoters. The effects of TCDD and selected hydroxyflavonoids alone (A) and in combination with TCDD (B) on recruitment of the AhR to the Ah-responsive region of the CYP1A1 gene promoter was determined in a ChIP assay. The effects of TCDD and selected hydroxyflavonoids alone (C) and in combination with TCDD (D) on recruitment of the AhR to the Ah-responsive region of the UGT1A1 gene promoter was determined in a ChIP assay.