Table 1.
AlCl3 in Drinking Water (ppm) |
|||
---|---|---|---|
0 (Control) | 900 | 1800 | |
PND 21 | |||
Males | |||
No. of offspring examined | 36 | 30 | 33 |
Body weight (g) | 17.9 ± 0.9 | 16.9 ± 1.3 | 15.6 ± 0.8** |
No. of offspring examined | 24 | 20 | 22 |
Brain weight (g) | 0.45 ± 0.02 | 0.44 ± 0.01 | 0.43 ± 0.01 |
(g/100g body weight) | 2.50 ± 0.15 | 2.65 ± 0.26 | 2.79 ± 0.18** |
Females | |||
No. of offspring examined | 24 | 20 | 22 |
Body weight (g) | 17.4 ± 0.7 | 15.7 ± 1.5** | 15.1 ± 0.7** |
Brain weight (g) | 0.44 ± 0.01 | 0.43 ± 0.01 | 0.43 ± 0.02* |
(g/100g body weight) | 2.58 ± 0.19 | 2.82 ± 0.24* | 2.90 ± 0.13** |
PND 77 | |||
Males | |||
No. of offspring examined | 32 | 23 | 39 |
Body weight (g) | 53.0 ± 2.8 | 53.0 ± 4.7 | 48.3 ± 2.1** |
No. of offspring examined | 20 | 13 | 28 |
Brain weight (g) | 0.50 ± 0.01 | 0.50 ± 0.02 | 0.50 ± 0.02 |
(g/100g body weight) | 0.98 ± 0.08 | 0.94 ± 0.10 | 1.04 ± 0.08 |
Females | |||
No. of offspring examined | 28 | 27 | 16 |
Body weight (g) | 42.5 ± 4.4 | 43.7 ± 2.7 | 40.5 ± 3.4 |
Brain weight (g) | 0.51 ± 0.02 | 0.49 ± 0.02 | 0.48 ± 0.03* |
(g/100g body weight) | 1.85 ± 0.08 | 1.89 ± 0.09 | 1.95 ± 0.17 |
Abbreviations: PND, postnatal day; AlCl3, aluminum chloride.
Data are expressed as the mean ± SD.
p < .05,
p < .01, compared with the 0-ppm controls by Dunnett’s test or Aspin-Welch’s t-test with Bonferroni correction.