Figure 7.

Vasoreactivity and serum cytokine changes following pulmonary exposure to Claim 28 and background PM₁₀. Serotonin-mediated contraction was enhanced following pharyngeal aspirations with Claim 28 PM₁₀ compared with vehicle control and Background PM₁₀ (A). Asterisks (*) indicate p < .05 compared with vehicle control and Background PM₁₀ by 2-way ANOVA with Tukey’s post hoc test, N = 6 per group. Serum obtained from both PM₁₀-treated mice, when coincubated with naïve aortic rings (ie, from unexposed mice) significantly impaired acetylcholine-mediated vasorelaxation (B). Of all cytokines measured in the serum (see Materials and Methods), only IL-5 was significantly affected by Claim 28 PM₁₀ (C). Asterisk (*) indicates significant difference from control (p < .05) by ANOVA with Tukey’s post hoc test, N = 6 per group.