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. Author manuscript; available in PMC: 2018 Dec 25.
Published in final edited form as: Eur J Med Chem. 2018 May 10;154:117–132. doi: 10.1016/j.ejmech.2018.05.011

Fig. 2.

Fig. 2

a) A representative N-phenylpyrrolamide D and its inhibitory activities on DNA gyrase and topoisomerase IV [16]; b) Structures of type I and type II N-phenylpyrrolamide inhibitors; c) Docking binding mode of inhibitor D coloured according to the atom chemical type (C, yellow; N, blue; O, red; Cl, green) in the ATP binding site of E. coli GyrB (in cyan, PDB code: 4DUH [22]). The water molecule is presented as a red sphere. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)