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. Author manuscript; available in PMC: 2018 Dec 25.
Published in final edited form as: Eur J Med Chem. 2018 May 10;154:117–132. doi: 10.1016/j.ejmech.2018.05.011

Scheme 2.

Scheme 2

Reagents and conditions: (a) hydrazine monohydrate, MeOH/THF, 65 °C, 15 h (for the synthesis of 10a) or 4 d (for the synthesis of 10b); (b) CDI, 1,4-dioxane/DMF, 100 °C, 15 h; (c) 4 M HCl in 1,4-dioxane, THF, rt, 5 h.