. Author manuscript; available in PMC: 2018 Dec 25.

Published in final edited form as: Eur J Med Chem. 2018 May 10;154:117–132. doi: 10.1016/j.ejmech.2018.05.011

Table 4.

Minimum inhibitory concentrations (MICs) of compounds 7c, 8a, 8d, 8e, 8f, 9a, 9b, 10a, 11a, 11b and 12 against S. aureus (ATCC 25923), E. faecalis (ATCC 29212) and E. coli (JW5503, a tolC deletion mutant).

Compd.	MIC (μM)^a

	S. aureus (ATCC 25923)	E. faecalis (ATCC 29212)	E. coli (JW5503) ΔtolC^b
7c	n.d.^c	n.d.	25 μM
8a	n.d.	>75 μM	n.d.
8d	n.d.	3.13 μM	n.d.
8e	n.d.	3.13 μM	50 μM
8f	n.d.	6.25 μM	n.d.
9a	50 μM	50 μM	25 μM
9b	50 μM	25 μM	25 μM
10a	n.d.	6.25 μM	n.d.
11a	3.13 μM	1.56 μM	n.d.
11b	n.d.	100 μM	n.d.
12	n.d.	n.d.	50 μM
ciprofloxacin	1.5 μM	3.0μM	0.015 μM

MIC (minimum inhibitory concentration that inhibits the growth of bacteria by ≥ 90%) values against E. faecalis, S. aureus and E. coli JW5503 (ΔtolC). Ciprofloxacin was used as a positive control.

E. coli strain with mutated efflux pump.

Not determined.