Fig. 7.

CAF p53 promotes tumor growth in SCID mice. mCherry-expressing H460 cells (5 × 10⁵) were injected, either alone or together, with 1.5 × 10⁶ immortalized NFs or CAFs (patient 4731) stably expressing either shLacZ or shp53, into the right flank of male SCID mice (n = 6 per group; total inoculation volume = 80 µL). (A) Tumors were excised and photographed 9 d later. (B) Relative tumor size was deduced from the photograph by calculating the tumor area with Fiji software (values are means ± SEM from six mice in each group). No Fib, no fibroblasts.