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. Author manuscript; available in PMC: 2018 Jun 25.
Published in final edited form as: Virology. 2015 May 15;483:149–162. doi: 10.1016/j.virol.2015.04.002

FIG. 4.

FIG. 4

In vivo SELEX of satC38. (A) Results of five rounds of passaging satC with 38 random bases replacing H2 (satC38). Sequences related to the three distinct “winning” satCs (samples Wh, Zh, and DDh) are boxed. Underlined nt denote differences between related satC clones. Second-site mutations are identified by symbols and defined at the bottom of the figure. (B) Secondary structure models for the 5′ region of SELEX winners Wh, Zh, and DDh. Results of SHAPE structure probing are shown on the model of Wh (see Fig. 1B for nucleotide coloring). Boxed nucleotides in Wh and DDh denote second-site mutations.