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A: Normal glucose and no stress conditions, p53 phosphorylated at Thr155 and interacts with Mdm2, enters to proteasomal degradation.
B: Hyperglycemia activates HBP, p53 get O-GlcNAcylated at Ser149. This modification prevents Thr155 phosphorylation, weakens p53 – Mdm2 interaction, p53 stabilized and activates its target proteins and apoptotic processes.
