Table 1.
Bioinformatics targets of miR-296 that were predicted and biologically validated in human and mouse
| miRNA Name | Target gene | Gene Description | Bioinformatics prediction tool | Biological validation |
|---|---|---|---|---|
| hsa-miR-296-5p | HMGA1 | high mobility group AT-hook 1 | miRDB, TargetScan | Yes |
| hsa-miR-296-5p | NUMBL | numb homolog (Drosophila)-like | miRDB, TargetScan | Yes |
| hsa-miR-296-5p | BOK | BCL2-related ovarian killer | miRDB | Yes |
| hsa-miR-296-3p | CX3CR1 | chemokine (C-X3-C motif) receptor 1 | miRDB | Yes |
| mmu-miR-296-5p | Pin1 | protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 | miRDB | Yes |
| hsa-miR-296-3p | PTEN | phosphatase and tensin homologue | TargetScan | Yes |
| hsa-miR-296-5p | NGFR | nerve growth factor receptor | TargetScan | Yes |
| hsa-miR-296-5p | FGFR1 | fibroblast growth factor receptor 1 | TargetScan | Yes |
| hsa-miR-296-3p | SOCS6 | suppressor of cytokine signaling 6 | miRDB, TargetScan | No |
| hsa-miR-296-5p | RNF44 | ring finger protein 44 | miRDB, TargetScan | No |
| hsa-miR-296-5p | EPN1 | epsin 1 | miRDB, TargetScan | No |
| hsa-miR-296-3p | ZBTB20 | zinc finger and BTB domain containing 20 | miRDB, TargetScan | No |
| mmu-miR-296-3p | ZBTB20 | zinc finger and BTB domain containing 20 | miRDB, TargetScan | No |
| mmu-miR-296-3p | STRN3 | striatin, calmodulin binding protein 3 | miRDB, TargetScan | No |
| hsa-miR-296-5p | LYPLA2 | lysophospholipase 2 | miRDB, TargetScan | No |
| mmu-miR-296-5p | DYRK1B | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b | miRDB, TargetScan | No |
| mmu-miR-296-5p | LYPLA2 | lysophospholipase 2 | miRDB, TargetScan | No |
| mmu-miR-296-5p | Srf | serum response factor | miRDB, TargetScan | No |
| mmu-miR-296-5p | SRRM3 | serine/arginine repetitive matrix 3 | miRDB, TargetScan | No |
| hsa-miR-296-3p | LMLN | leishmanolysin-like (metallopeptidase M8 family) | miRDB | No |
| hsa-miR-296-3p | KLHL23 | kelch-like family member 23 | miRDB | No |
| hsa-miR-296-3p | ZNF117 | zinc finger protein 117 | miRDB | No |
| hsa-miR-296-3p | CADPS | Ca++-dependent secretion activator | miRDB | No |
| hsa-miR-296-3p | NTF3 | neurotrophin 3 | miRDB | No |
| -hsa-miR-296-5p | TEAD3 | TEA domain family member 3 | TargetScan | No |
| hsa-miR-296-5p | BBC3 | BCL2 binding component 3 | TargetScan | No |
| hsa-miR-296-5p | ISCA2 | iron-sulfur cluster assembly 2 | TargetScan | No |
| hsa-miR-296-5p | RIMS4 | regulating synaptic membrane exocytosis 4 | TargetScan | No |
| mmu-miR-296-3p | SOCS6 | suppressor of cytokine signaling 6 | TargetScan | No |