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. 2018 May 3;24:18. doi: 10.1186/s10020-018-0020-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Decreased positive expression rate of CREB1 and increased Cleaved Caspase-3 in the hippocampal CA1 area of mice injected with shCREB1–1 or/and H89, Notes: A, the immunohistochemical staining results of CREB1 in each group (× 200); B, the histogram of the CREB1 average OD; C, the immunohistochemical staining results of Cleaved Caspase-3 in each group (× 200); D, the histogram of the Cleaved Caspase-3 average OD; ^*, p < 0.05, compared with the normal group; ^#, p < 0.05, compared with the VD group; CREB1, cyclic adenosine monophosphate responsive element-binding protein 1; CA1, cornu ammonis 1; VD, vascular dementia; OD, optical density