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Increased neuronal apoptosis in hippocampal CA1 area of mice injected with shCREB1–1 or/and H89, Notes: A, the TUNEL staining results of CA1 in hippocampus of mice in each group (× 200); B, the histogram of apoptotic index of hippocampal CA1 neurons of mice in each group; *, p < 0.05, compared with the normal group; #, p < 0.05, compared with the VD group; CREB1, cyclic adenosine monophosphate responsive element-binding protein 1; VD, vascular dementia
