Fig. 1.

Time dependent effects of a high salt diet (HSD) on Dahl salt-sensitive rat cardiac function and hypertrophy. a Diastolic dysfunction was measured by E’/A’. b %EF was measured by echocardiography. c Cardiac work was measured during the isolated working heart perfusions. d-e Cardiac hypertrophy was measured by corrected LV mass and LVPWd using echocardiography. f Cardiac p-p70S6K/p70S6K protein expression was assessed in hearts obtained at each of the time periods studied. Measurements were made in Dahl salt-sensitive rats fed a low salt diet, 0.3% NaCl (Control) or a HSD, 8% NaCl, for 3, 6, or 9 weeks. n = 5–8 * p < 0.05 compared to Control. # p < 0.05 compared to 3 weeks. t p < 0.05 compared to 6 weeks. Values shown as mean ± SEM