Table 1.
Effect of a high salt diet (HSD) on in vivo cardiac function in Dahl salt-sensitive rats
| Control | 3 weeks | 6 weeks | 9 weeks | |
|---|---|---|---|---|
| EF (%) | 83.79 ±1.44 | 82.21 ±2.50 | 84.91 ±1.14 | 76.21 ±2.19T |
| FS (%) | 54.60 ±1.69 | 53.12 ±2.57 | 54.45 ±2.39 | 47.64 ±2.34 |
| LV Mass Corrected | 962.88 ±43.45 | 1045.85 ±36.11 | 1167.85 ±38.96* | 1328.94 ±52.37*# |
| IVSd (mm) | 1.97 ±0.05 | 2.23 ±0.06* | 2.40 ±0.07* | 2.50 ±0.07*# |
| LVIDd (mm) | 7.91 ±0.12 | 7.32 ±0.14* | 7.45 ±0.09 | 7.52 ±0.20 |
| LVPWd (mm) | 1.98 ±0.03 | 2.23 ±0.06 | 2.49 ±0.10* | 2.50 ±0.08* |
| IVSs (mm) | 3.40 ±0.05 | 3.67 ±0.10 | 3.68 ±0.09 | 3.68 ±0.15 |
| LVIDs (mm) | 3.87 ±0.18 | 3.46 ±0.23 | 3.40 ±0.09 | 4.25 ±0.08 |
| LVPWs (mm) | 3.45 ±0.12 | 3.68 ±0.11 | 3.77 ±0.08 | 3.65 ±0.13 |
| LV Vol;d | 335.75 ±10.95 | 283.11 ±12.35* | 294.62 ±7.78 | 301.74 ±17.16 |
| LV Vol;s | 51.99 ±6.28 | 45.76 ±6.96 | 47.51 ±3.37 | 81.30 ±3.62*#T |
| E/E’ | 19.04 ±2.18 | 20.49 ±1.95 | 18.82 ±1.22 | 18.29 ±1.51 |
| E/A | 1.60 ±0.11 | 1.64 ±0.07 | 1.33 ±0.15 | 1.40 ±0.20 |
| E’/A’ | 0.98 ±0.04 | 0.85 ±0.03 | 0.81 ±0.02* | 0.76 ±0.07* |
| Tei Index | 0.65 ±0.03 | 0.72 ±0.04 | 0.78 ±0.05 | 0.76 ±0.05 |
| E’ | 54.23 ±6.85 | 54.68 ±4.61 | 46.79 ±2.14 | 38.26 ±3.49 |
| IVRT (ms) | 24.32 ±0.60 | 22.68 ±0.68 | 27.97 ±1.76 | 28.13 ±1.63 |
| IVCT (ms) | 15.69 ±0.90 | 16.88 ±1.29 | 15.81 ±1.48 | 17.47 ±1.43 |
| HR (bpm) | 365.25 ±6.61 | 375.88 ±7.71 | 367.63 ±10.98 | 349.75 ±16.68 |
| L Kidney/TL (g/cm) | 0.31 ±0.01 | 0.34 ±0.01 | 0.34 ±0.01 | 0.38 ±0.03* |
In vivo cardiac function was measured via echocardiography in Dahl salt-sensitive rats fed a low salt diet, 0.3% NaCl (Control), or a high salt diet, 8% NaCl, for 3, 6, or 9 weeks. n = 5–8 * p < 0.05 compared to Control. * p < 0.05 compared to Control. # p < 0.05 compared to 3 weeks. T p < 0.05 compared to 6 weeks. n = 6–9 Values shown as mean ±SEM % Ejection fraction (%EF); % Fractional shortening (%FS); left ventricle (LV); Interventricular septum end diastole (IVSd); LV internal diameter end diastole (LVIDd); LV posterior wall thickness end diastole (LVPWd); Interventricular septum end systole (IVSs); LV internal diameter end systole (LVIDs); LV posterior wall thickness end systole (LVPWs); LV volume end diastole (LV Vol;d); LV volume end systole (LV Vol;s); Isovolumetic relaxation time (IVRT); Isovolumetic contraction time (IVCT); Tibia length (TL); Heart rate (HR)