Table 2.
Effect of a high salt diet (HSD) on cardiac function ex vivo in Dahl salt-sensitive rats
| Control | 3 weeks | 6 weeks | 9 weeks | |
|---|---|---|---|---|
| Heart rate (beats●min− 1) | 277.9 ±7.3 | 290.8 ±8.6 | 278.7 ±6.1 | 266.9 ±22.9 |
| Peak Systolic Pressure (mmHg) | 109.9 ±1.0 | 107.8 ±2.6 | 110.8 ±1.7 | 107.5 ±6.7 |
| Developed Pressure (mmHg) | 41.9 ±2.8 | 38.5 ±3.8 | 42.6 ±2.2 | 43.1 ±7.0 |
| Cardiac Output (ml●min−1) | 50.4 ±2.2 | 45.7 ±1.9 | 41.6 ±2.2 | 38.5 ±3.1* |
| Coronary Flow (ml●min−1) | 26.5 ±2.8 | 23.9 ±0.5 | 22.3 ±0.7 | 20.8 ±1.5 |
| Cardiac Work (joules●min− 1●g dry weight− 1) | 2.1 ±0.1 | 1.9 ±0.1 | 1.6 ±0.1* | 1.4 ±0.2* |
Cardiac function was measured in isolated working hearts from Dahl salt-sensitive rats fed a low salt diet, 0.3% NaCl (Control), or a high salt diet, 8% NaCl, for 3, 6, or 9 weeks. n = 3–5 * p < 0.05 compared to Control. Values shown as mean ±SEM