Fig. 7.

Ethyl pyruvate inhibits NLRP3 agonists-induced inflammasome activation in human macrophages. Human macrophages were primed with ultra-pure LPS (1 μg/ml) for 3 h. in the presence or the absence of EP (1 or 5 mM), and then stimulated with ATP (5 mM) for 30 min. a IL-1β level and (b) IL-6, TNF production were determined by ELISA. Results are means ± SEM (n = 3). *p < 0.05; **p < 0.01; ***p < 0.001