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. 2018 May 16;24:23. doi: 10.1186/s10020-018-0022-9

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Immune gene mRNA repertoires of stratified human keratinocytes from different anatomical sites vary significantly. Results are for SHKs grown in organotypic cultures from a pool of 3–5 individuals and represent 3 independent samples of each of the mucosal sites shown (baseline and HPV infected). Data were log transformed, and normalized to the median. Eighty one “immunologic genes” are shown, and a principle component analysis (PCA) performed (dots = genes; lines with arrows = tissue types; axis 3 PCA). Tissue types were separated (PC1, PC2, and PC3), to demonstrate differential genetic expression patterns for these genes. Heat maps and the PCA for SHKs from each site are shown for resting (a, d), HPV16 transfected (b, e), and HPV16⁻ or HPV16⁺ keratinocytes from all sites separately grouped together (c, f)