Table 2. Summary of serology, skin testing and Mueller grading for the Slovenian mono-sensitized population.
| Bee | Wasp | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pat. no. |
t-IgE CAP a) |
bee CAP b) |
wasp CAP c) |
Skin test Bee/Wasp d) |
rApi m 1 Chip e) CAP f) |
rApi m 2 ELISA g) |
rApi m 3 CAP h) |
rApi m 4 Chip i) |
rApi m 5 CAP j) |
rApi m 10 CAP k) |
rVes v 5 Chip l) CAP m) |
rVes v 1 ELISA n) |
Mueller Grade o) |
culprit insect p) |
||
| kU/L | kUA/L | kUA/L | Venom | ISU | kUA/L | O.D. | kUA/L | ISU | kUA/L | kUA/L | ISU | kUA/L | O.D. | |||
| S1 | n.d. | 2.45 | <0.35 | 10/neg | 0.6 | 1.05 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | 0 | 2 | b |
| S2 | 17.7 | 7.82 | <0.35 | 10/neg | 0.25 | 1.59 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | 0 | 2 | b |
| S3 | 44.8 | 8.57 | <0.35 | 10/neg | 0.49 | 3.48 | 0 | 0.14 | 0.36 | 1.9 | <0.1 | <0.1 | <0.1 | 0 | 4 | b |
| S4 | n.d. | 2.85 | <0.35 | 10/neg | 0.21 | 1.31 | 0.45 | n.d. | 0.14 | n.d. | 0.3 | <0.1 | <0.1 | 0 | 3 | b |
| S5 | n.d. | 1.38 | <0.35 | 100/neg | 0.12 | 0.17 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | 0 | 1 | b |
| S6 | n.d. | 15.9 | <0.35 | 10/100 | 1.3 | 1.59 | 0.53 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | 0 | 0 (LLR) | b |
| S7 | 212 | 17 | <0.35 | 10/100 | 0.83 | 7.49 | 0 | <0.1 | <0.1 | 6.1 | 2.53 | <0.1 | <0.1 | 0 | 3 | b |
| S8 | n.d. | 2.45 | <0.35 | 10/neg | 0.6 | 0.28 | 0 | <0.1 | <0.1 | n.d. | <0.1 | <0.1 | <0.1 | 0 | 2 | b |
| S9 | n.d. | 1.69 | <0.35 | neg/neg | 0.29 | 0.69 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | 0 | 0 (LLR) | b |
| S10 | n.d. | 10.7 | <0.35 | neg/neg | <0.1 | <0.1 | 0.69 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | <0.1 | 0 | 1 | b |
| S11 | 57.1 | 10.9 | <0.35 | 10/neg | 0.92 | 2.63 | 0 | n.d. | 0.32 | n.d. | 16.1 | <0.1 | <0.1 | 0 | 2 | b |
| S12 | 189 | <0.35 | 2.3 | 100/100 | <0.1 | <0.1 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | 1.11 | 1.24 | 0 | 4 | w |
| S13 | 224 | <0.35 | 1.96 | neg/10 | <0.1 | <0.1 | 0 | <0.1 | <0.1 | 0.28 | <0.1 | 2.35 | 1.53 | 0.58 | 3 | w |
| S14 | 84.7 | <0.35 | 11.2 | neg/10 | <0.1 | <0.1 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | 0.73 | 0.69 | 0.29 | 3 | w |
| S15 | 638 | <0.35 | 4.67 | neg/10 | <0.1 | <0.1 | 0 | n.d. | <0.1 | n.d. | <0.1 | 1.09 | 1.43 | 0.37 | 2 | w |
| S16 | 435 | <0.35 | 9.05 | neg/100 | <0.1 | <0.1 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | 2.38 | 2.66 | 0 | 2 | w |
| S17 | 96 | <0.35 | 1.94 | neg/10 | <0.1 | <0.1 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | 0.67 | 0.58 | 0.28 | 3 | w |
| S18 | 61.6 | <0.35 | 3.57 | neg/10 | <0.1 | <0.1 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | 2.39 | 2.02 | 0.41 | 4 | w |
| S19 | 171 | <0.35 | 8.19 | neg/100 | <0.1 | <0.1 | 0 | <0.1 | <0.1 | 0.43 | <0.1 | 3.44 | 3.16 | 0 | 2 | w |
| S20 | 61.5 | <0.35 | 4.93 | neg/10 | <0.1 | <0.1 | 0 | <0.1 | <0.1 | <0.1 | <0.1 | 3.41 | 5.29 | 0 | 4 | w |
a) total IgE, ImmunoCAP
b) bee venom sIgE, ImmunoCAP
c) wasp venom sIgE, ImmunoCAP
d) skin prick test; given is the threshold concentration of a positive skin reaction
10 μg/ml, 100 μg/ml, neg: no reaction
e) IgE-reactivity to non-glycosylated rApi m 1 measured by allergen micro-array
f) IgE-reactivity to non-glycosylated rApi m 1 measured by ImmunoCAP
g) IgE-reactivity to non-glycosylated rApi m 2 measured by ELISA
h) IgE-reactivity to non-glycosylated rApi m 3 measured by ImmunoCAP
i) IgE-reactivity to rApi m 4 measured by allergen micro-array
j) IgE-reactivity to non-glycosylated rApi m 5 measured by ImmunoCAP
k) IgE-reactivity to non-glycosylated rApi m 10 measured by ImmunoCAP
l) IgE-reactivity to rVes v 5 measured by allergen micro-array
m) IgE-reactivity to rVes v 5 measured by ImmunoCAP
n) IgE-reactivity to rVes v 1 measured by ELISA
o) clinical severity in Mueller grade or large local reaction
p) according to component-resolved diagnosis
Abbr: n.d.: not done, O.D.: optical density, LLR: large local reaction, b: bee, w: wasp
IgE-levels ≥ 0.1 ISU, ≥ 0.35 kUA/L are highlighted in grey