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. 2018 Jan 2;23(1):91. doi: 10.3390/molecules23010091

Figure 2.

Figure 2

Histopathologic examination of synoviumin in AA rats (HE, 200×). (A) Non-immunized rats: no synovium hyperplasia and inflammatory cells infiltration were observed; (B) AA rats: inflammatory cells infiltration, synovium hyperplasia, and pannus formation were markedly observed. Arrows a, b, and c represent inflammatory cell infiltration, synovium hyperplasia and pannus formation, respectively; (C) AA rats treated with GE (30 mg/kg): a clear synovium hyperplasia and inflammatory cell infiltration; (D) AA rats treated with GE (60 mg/kg): synovium hyperplasia and inflammatory cells infiltration were obviously reduced; (E) AA rats treated with GE (120 mg/kg): little synovium hyperplasia were observed; (F) AA rats treated with SIN (90 mg/kg): fewer synovium hyperplasia and inflammatory cell infiltration were observed.